File:PegUricase.png
Size of this preview: 615 × 599 pixels. Other resolutions: 246 × 240 pixels | 493 × 480 pixels | 788 × 768 pixels | 1,051 × 1,024 pixels | 2,192 × 2,136 pixels.
Original file (2,192 × 2,136 pixels, file size: 1.65 MB, MIME type: image/png)
Summary
| Description |
English: A comparison of uricase (pdb:1uox) and PEG-uricase (model). PEG-uricase includes 40 polymers of 10kDa PEG. PEGylation improves its solubility at physiological pH, increases serum half-life and reduces immunogenicity without compromising activity. Upper images show the whole tetramer, lower images show an example of one of the lysines that is PEGylated. (PEG-uricase model from reference[1], only 36 PEG polymers included) |
| Date | |
| Source | Own work |
| Author | Evolution and evolvability |
Licensing
I, the copyright holder of this work, hereby publish it under the following license:
This file is licensed under the Creative Commons Attribution 4.0 International license.
- You are free:
- to share – to copy, distribute and transmit the work
- to remix – to adapt the work
- Under the following conditions:
- attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- ↑ (3 January 2008). "PEG-uricase in the management of treatment-resistant gout and hyperuricemia.". Advanced drug delivery reviews 60 (1): 59-68. PMID 17826865.
File history
Click on a date/time to view the file as it appeared at that time.
| Date/Time | Thumbnail | Dimensions | User | Comment | |
|---|---|---|---|---|---|
| current | 23:50, 21 February 2015 | | 2,192 × 2,136 (1.65 MB) | Evolution and evolvability | User created page with UploadWizard |
File usage
There are no pages that use this file.
